Research and Publications

Dr. Fadel's clinical research covers laser ablation for brain tumors, outcomes after cranial and spinal surgery, and opioid stewardship after neurosurgical procedures. His work appears in the Journal of Neurosurgery, Neurosurgery, the Journal of Neuro-Oncology, the American Journal of Neuroradiology, Spine, World Neurosurgery, Neurosurgical Focus, and Journal of Neurosurgery: Case Lessons.

His ORCID record is at 0000-0001-9975-5160.

Laser Ablation for Brain Tumors

Work on laser interstitial thermal therapy for glioma, glioblastoma and brain metastases, including outcomes compared with open surgery.

• Laser Interstitial Thermal Therapy for Intra-Axial Brain Tumors: Everything the Neuroradiologist Should Know. American Journal of Neuroradiology. Review.
• Laser interstitial thermal therapy for deep-seated perivascular brain tumors is not associated with distal ischemia. Journal of Neuro-Oncology. Original research.
• Laser interstitial thermal therapy for first-line treatment of insular glioma. Journal of Neurosurgery. Original research.
• Laser Interstitial Thermal Therapy for First-Line Treatment of Surgically Accessible Recurrent Glioblastoma: Outcomes Compared With a Surgical Cohort. Neurosurgery. Original research.
• In Reply: Laser Interstitial Thermal Therapy for First-Line Treatment of Surgically Accessible Recurrent Glioblastoma: Outcomes Compared With a Surgical Cohort. Neurosurgery. Author reply to correspondence about the study above.
• SURG-22. STAGED LASER INTERSTITIAL THERAPY (LITT) FOR THE SURGICAL TREATMENT OF INSULAR GLIOMA: A CASE SERIES WITH A NOVEL TREATMENT PARADIGM. Neuro-Oncology, 2022. Conference abstract, presented in advance of the insular glioma paper above.
• SURG-14. Laser Ablation for Brain Metastases: Risk Factors for Neurologic Complication. Neuro-Oncology Advances, 2021. Conference abstract.
• SURG-17. EFFICACY AND SAFETY OF LASER INTERSTITIAL THERMAL ABLATION IN ELDERLY BRAIN TUMOR PATIENTS. Neuro-Oncology, 2020. Conference abstract.
• SURG-16. PREDICTORS OF LOCAL CONTROL FOLLOWING LASER INTERSTITIAL THERMAL THERAPY FOR GLIAL TUMORS. Neuro-Oncology, 2020. Conference abstract.
• SURG-13. LASER INTERSTITIAL THERMAL THERAPY FOR RECURRENT GLIOBLASTOMA: A REVIEW OF SURVIVAL OUTCOMES COMPARED TO A MATCHED SURGICAL COHORT. Neuro-Oncology, 2020. Conference abstract, presented in advance of the recurrent glioblastoma comparison above.

Cranial Nerve Tumors, Brain Tumor Genomics and Laboratory Research

Fractionated radiotherapy for two pediatric cranial nerve schwannomas, meningioma genomics, and laboratory research on tumor metabolism and animal models.

• Oculomotor Schwannomas: A Systematic Review and Report of Two Pediatric Cases Treated with Fractionated Cyberknife Stereotactic Radiotherapy. World Neurosurgery. Systematic review and two cases.
• Genomic Biomarkers of Meningioma: A Focused Review. International Journal of Molecular Sciences. Review.
• Investigation of the aryl hydrocarbon receptor and the intrinsic tumoral component of the kynurenine pathway of tryptophan metabolism in primary brain tumors. Journal of Neuro-Oncology. Laboratory research.
• Animal models of primary brain tumors. In Animal Models in Cancer Drug Discovery. Book chapter.
• CSIG-17. TARGETING THE KYNURENINE PATHWAY OF TRYPTOPHAN METABOLISM IN PATIENT-DERIVED MELANOMA BRAIN METASTATIC CELLS. Neuro-Oncology, 2017. Conference abstract.

Spine Surgery

Cervical, thoracic and lumbar surgery, including four studies drawn from the Michigan Spine Surgery Improvement Collaborative registry.

• Clinical Outcomes of Decompressive Spine Surgery for Painless Cervical Myelopathy: Analysis of the Michigan Spine Surgery Improvement Collaborative Registry. Neurosurgery. Original research.
• Risk Factors of Long-Term Opioid Use After Elective Cervical and Lumbar Spine Surgery: A Michigan Spine Surgery Improvement Collaborative Study. Neurosurgery. Original research.
• Compressive myelopathy from diffuse spinal dural calcifications in a patient with end-stage renal disease: illustrative case. Journal of Neurosurgery: Case Lessons. Case report.
• The Potential Negative Effects of Smoking on Cervical and Lumbar Surgery Beyond Pseudarthrosis: A Michigan Spine Surgery Improvement Collaborative Study. World Neurosurgery. Original research.
• A Matched Cohort Analysis of Drain Usage in Elective Anterior Cervical Discectomy and Fusion: A Michigan Spine Surgery Improvement Collaborative (MSSIC) Study. Spine. Original research.
• Surgical management of Grisel syndrome in the adult patient: illustrative case. Journal of Neurosurgery: Case Lessons. Case report.
• The influence of sagittal spinopelvic alignment on patient discharge disposition following minimally invasive lumbar interbody fusion. Journal of Spine Surgery. Original research.
• The 25 most cited articles on lateral lumbar interbody fusion: short review. Neurosurgical Review. Bibliometric review.

Traumatic Brain Hemorrhage, Cerebrovascular Disease and Shunt Infection

Hematoma expansion in small- to moderate-sized traumatic intraparenchymal hemorrhage, revascularization for intracranial steno-occlusive disease, and a fungal shunt infection.

• The Effect of Antithrombotics on Hematoma Expansion in Small- to Moderate-Sized Traumatic Intraparenchymal Hemorrhages. World Neurosurgery. Original research.
• Effect of revascularization on cognitive outcomes in intracranial steno-occlusive disease: a systematic review. Neurosurgical Focus. Systematic review.
• Candida parapsilosis Infection of Ventriculoperitoneal Shunt in Adult: Case Report and Literature Review. World Neurosurgery. Case report and literature review.

Practice Improvement and Patient-Centered Care

Reducing opioid prescribing after craniotomy, and patient-centered care in a brain tumor center.

• Reducing Superfluous Opioid Prescribing Practices After Brain Surgery: It Is Time to Talk About Drugs. Neurosurgery. Original research.
• INNV-14. UTILIZATION OF A PATIENT FAMILY ADVISORY COUNCIL TO ADVANCE PATIENT-CENTERED CARE OF BRAIN TUMOR PATIENTS. Neuro-Oncology, 2020. Conference abstract.